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All medicines have risks and benefitsYour doctor will have weighed the risks of you taking TOPROL-XL against the benefits they expect it will have for you.

Tell your doctor or pharmacist immediately if you notice any of the following:

Beta-blockers may mask tachycardia occurring with hypoglycemiabut other manifestations such as dizziness and sweating may not be significantly affected.

Central Nervous SystemReversible mental depression progressing to catatoniaan acute reversible syndrome characterized by disorientation for time and placeshort-term memory lossemotional labilityclouded sensoriumand decreased performance on neuropsychometrics.

Clinical pharmacology studies have confirmed the beta-blocking activity of metoprolol in manas shown by1reduction in heart rate and cardiac output at rest and upon exercise2reduction of systolic blood pressure upon exercise3inhibition of isoproterenol-induced tachycardiaand4reduction of reflex orthostatic tachycardia.

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