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If you are using the nasal spray, the imitrex dose is 5 mg, 10 mg, or 20 mg sprayed into one nostril.

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Taking MAO inhibitors with this medication may cause a seriouspossibly fataldrug interactionDo not take any MAO inhibitorsisocarboxazidlinezolidmethylene bluemoclobemidephenelzineprocarbazinerasagilinesafinamideselegilinetranylcypromineduring treatment with this medicationMost MAO inhibitors should also not be taken for two weeks before treatment with this medicationAsk your doctor when to start or stop taking this medication.

Serotonin syndrome may occur with Imitrex tabletsparticularly during coadministration with selective serotonin reuptake inhibitorsSSRIsserotonin norepinephrine reuptake inhibitorsSNRIstricyclic antidepressantsTCAsand MAO inhibitorssee Drug Interactions7.4Serotonin syndrome symptoms may include mental status changese.gagitationhallucinationscomaautonomic instabilitye.gtachycardialabile blood pressurehyperthermianeuromuscular aberrationse.ghyperreflexiaincoordinationand/or gastrointestinal symptomse.gnauseavomitingdiarrheaThe onset of symptoms usually occurs within minutes to hours of receiving a new or a greater dose of a serotonergic medicationDiscontinue Imitrex tablets if serotonin syndrome is suspected.

It is unclear whether the nausea and vomiting is related to sumatriptan therapy or to the underlying condition.

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