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Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effectsMany people using this medication do not have serious side effects.
The use of galantamine is not recommended in patients with urinary outflow obstruction or recovering from bladder surgery.
Because of its mechanism of actiongalantamine should not be given concomitantly with other cholinomimeticssuch as ambenoniumdonepezilneostigminepyridostigminerivastigmine or systemically administered pilocarpineGalantamine has the potential to antagonise the effect of anticholinergic medicationShould anticholinergic medication such as atropine be abruptly stopped there is a potential risk that galantamine’s effects could be exacerbatedAs expected with cholinomimeticsa pharmacodynamic interaction is possible with medicinal products that significantly reduce the heart rate such as digoxinbeta blockerscertain calcium-channel blocking agents and amiodaroneCaution should be taken with medicinal products that have potential to cause torsades de pointesIn such cases an ECG should be considered.
Patients at increased risk of developing peptic ulcerse.gthose with a history of ulcer disease or those predisposed to these conditionsincluding those receiving concurrent non-steroidal anti-inflammatory drugsNSAIDSshould be monitored for symptomsThe use of galantamine is not recommended in patients with gastro-intestinal obstruction or recovering from gastro-intestinal surgery.
Because no data are available on the use of galantamine in patients with severe hepatic impairmentChild-Pugh score greater than 9and in patients with creatinine clearance less than 9 ml/mingalantamine is contraindicated in these populationsGalantamine is contraindicated in patients who have both significant renal and hepatic dysfunction.
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