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Tinidazolelike metronidazolemay produce transient leukopenia and neutropeniahoweverno persistent hematological abnormalities attributable to tinidazole have been observed in clinical studiesTotal and differential leukocyte counts are recommended if re-treatment is necessary.
Simultaneous administration of tinidazole with drugs that induce liver microsomal enzymesi.eCYP3A4 inducers such as phenobarbitalrifampinphenytoinand fosphenytoina pro-drug of phenytoinmay accelerate the elimination of tinidazoledecreasing the plasma level of tinidazoleSimultaneous administration of drugs that inhibit the activity of liver microsomal enzymesi.eCYP3A4 inhibitors such as cimetidine and ketoconazolemay prolong the half-life and decrease the plasma clearance of tinidazoleincreasing the plasma concentrations of tinidazole.
Oxytetracycline was reported to antagonize the therapeutic effect of metronidazole.
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