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ClomiPHENE citrate is capable of interacting with estrogen-receptor-containing tissuesincluding the hypothalamuspituitaryovaryendometriumvaginaand cervixIt may compete with estrogen for estrogen-receptor-binding sites and may delay replenishment of intracellular estrogen receptorsClomiPHENE citrate initiates a series of endocrine events culminating in a preovulatory gonadotropin surge and subsequent follicular ruptureThe first endocrine event in response to a course of clomiPHENE citrate therapy is an increase in the release of pituitary gonadotropinsThis initiates steroidogenesis and folliculogenesisresulting in growth of the ovarian follicle and an increase in the circulating level of estradiolFollowing ovulationplasma progesterone and estradiol rise and fall as they would in a normal ovulatory cycle.

The following adverse events have been reported in fewer than 1of patients in clinical trialsAcute abdomenappetite increaseconstipationdermatitis or rashdepressiondiarrheadizzinessfatiguehair loss/dry hairincreased urinary frequency/volumeinsomnialight-headednessnervous tensionvaginal drynessvertigoweight gain/loss.

5Uterine FibroidsCaution should be exercised when using clomiPHENE citrate in patients with uterine fibroids due to the potential for further enlargement of the fibroids.

Do not take clomiphene if you are pregnantClomiphene is in the FDA pregnancy category XThis means that it is known to cause birth defects.

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