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Nimodipine is a calcium channel blockerThe contractile processes of smooth muscle cells are dependent upon calcium ionswhich enter these cells during depolarization as slow ionic transmembrane currentsNimodipine inhibits calcium ion transfer into these cells and thus inhibits contractions of vascular smooth muscleIn animal experimentsnimodipine had a greater effect on cerebral arteries than on arteries elsewhere in the body perhaps because it is highly lipophilicallowing it to cross the blood-brain barrierconcentrations of nimodipine as high as 12.5 ng/mL have been detected in the cerebrospinal fluid of nimodipine-treated subarachnoid hemorrhageSAHpatients.

There are no adequate and well controlled studies in pregnant womenNo reproductive toxicology studies following parenteral administration are availableReproductive toxicology studies in animals after oral administration showed no teratogenic effectalthough studies in animals have shown reproductive toxicitysee section 5.3If Nimotop solution is to be administered during pregnancythe benefits and the potential risks mustthereforebe carefully weighed according to the severity of the clinical picture.

The precise mechanism of action of nimodipine in humans is unknownAlthough the clinical studies described below demonstrate a favorable effect of nimodipine on the severity of neurological deficits caused by cerebral vasospasm following SAHthere is no arteriographic evidence that the drug either prevents or relieves the spasm of these arteriesHoweverwhether or not the arteriographic methodology utilized was adequate to detect a clinically meaningful effectif anyon vasospasm is unknown.

Get emergency medical help if you have any of these signs of an allergic reactionhivesdifficult breathingswelling of your facelipstongueor throat.

Liver diseaselow blood pressurehigh blood pressure for which you take medicationor a history of heart problems such as a slow heart ratecongestive heart failureor heart attack.

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